Here's how anastrozole works:
Aromatase Inhibition: Anastrozole inhibits the activity of the enzyme aromatase. Aromatase is responsible for converting androgens (hormones produced by the adrenal glands) into estrogen. In postmenopausal women, estrogen is often produced in peripheral tissues through this conversion process. Hormone receptor-positive breast cancer cells rely on estrogen for growth.
Estrogen Reduction: By inhibiting aromatase, anastrozole reduces the levels of estrogen in the body. Lower estrogen levels can slow down or stop the growth of hormone receptor-positive breast cancer cells.
| Uses |
Anastrozole has significant effects on breast cancer treatment and, therefore, it is currently used as first-line treatment in estrogen receptor (ER)-positive postmenopausal women, particularly to treat locally advanced or metastatic breast cancer. Furthermore, it is also indicated for early cancer treatment, tumor chemoprevention and postmenopausal women using tamoxifen, especially if the drug is used during a prolonged period of time and has been indicated in the disease’s recurrence, i.e., as another therapeutic endocrine option. |
Anastrozole is commonly prescribed as part of adjuvant therapy for postmenopausal women with early-stage breast cancer, particularly those at higher risk of disease recurrence. It may also be used in advanced-stage breast cancer when the disease has spread or metastasized.
It's important to note that anastrozole is not used to treat breast cancer in premenopausal women, as their ovaries are the primary source of estrogen production.
As with any medication, anastrozole may have side effects, and its use should be guided by a healthcare professional based on an individual's specific medical history and needs. If you have questions about the use of anastrozole or its potential side effects, it's best to consult with a healthcare provider.
Differences between Letrozole Tablets and Anastrozole: Anastrozole is a potent selective triazole aromatase inhibitor that inhibits aromatase dependent on cytochrome P-450, blocking the biosynthesis of estrogen. Estrogen is a major factor stimulating the growth of breast cancer cells. The IC50 value for this product in inhibiting 50% of human placental aromatase is 15 nmol/L. Letrozole is suitable for late-stage postmenopausal breast cancer, often used as second-line treatment after the failure of anti-estrogen therapy. Anastrozole is poised to become the standard for adjuvant breast cancer therapy, as the largest and longest-followed global clinical trial of aromatase inhibitors for adjuvant breast cancer therapy has yielded the latest results.
Compared to the traditional drug tamoxifen, Anastrozole can comprehensively and effectively reduce the risk of breast cancer recurrence and metastasis, prolonging the disease-free survival of patients. Even after completing the standard course of 4 years, the protective effect of Anastrozole persists. Professor Xu Binghe, Deputy Director of the Department of Oncology at the Cancer Hospital of the Chinese Academy of Medical Sciences, suggested that this marks Anastrozole becoming the standard regimen for adjuvant endocrine therapy for breast cancer. Traditional postoperative endocrine drugs for breast cancer are often triphenylethylene.
Triphenylethylene has many side effects, such as inducing endometrial cancer and thromboembolism. This clinical trial compared the effects of the third-generation aromatase inhibitor Anastrozole with triphenylethylene. The trial involved 381 centers in 21 countries, making it a global multicenter clinical trial. Since 1996, a total of 9,366 patients participated in the trial, with a follow-up time of 100 months. The Anastrozole group had a recurrence rate of 25.8%, while the triphenylethylene group had a recurrence rate of 29.9%. Anastrozole reduced the recurrence rate by 4.1% compared to triphenylethylene and also reduced the risk of distant metastasis. Anastrozole also outperformed triphenylethylene in terms of safety.
Chemical Properties: Crystalline from ethyl acetate-cyclohexane, melting point 81-82°C. Uses: Third-generation aromatase inhibitor. Used to treat late-stage breast cancer in postmenopausal patients.
Used for treating breast cancer. Potent selective triazole aromatase inhibitor that inhibits aromatase dependent on cytochrome P-450, blocking the biosynthesis of estrogen—a major factor stimulating the growth of breast cancer cells.
Used in the treatment of breast cancer, especially suitable for late-stage breast cancer in postmenopausal women who have relapsed after hormone therapy.
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