Discover Ipamorelin-It is a synthetic peptide that belongs to the class of growth hormone secretagogues.
Understanding Ipamorelin
Ipamorelin is sometimes used by athletes and bodybuilders to enhance performance and promote muscle growth. The mechanism of action in this context is based on its ability to increase the production of growth hormone, which can lead to improved muscle mass and recovery.
Specifications
|
CAS |
170851-70-4 |
|
OTHER KNOWN TITLES |
Ipamorelin |
|
MOLECULAR WEIGHT |
711.85296 g/mol |
|
MOLECULAR FORMULA |
C38H49N9O5 |
Ipamorelin Research
IPAMORELIN AND BONE
Lessened bone density over prolonged periods may lead to fracture. Ipamorelin studies in rats have observed that the peptide may prevent bone loss following prolonged glucocorticoid exposure, and also may induce up to a four-fold increase in bone formation.[3] The researchers also reported that “the decrease in muscle strength and bone formation found in GC-rats was counteracted by simultaneous administration of the growth hormone secretagogue.” The peptide may potentially improve the bone mineral density of both existing and new bones. Additionally, it may possibly mitigate or reverse ancillary impacts such as muscle wasting and fat deposition in visceral organs.
IPAMORELIN AND DIABETES
Studies in murine models of diabetes have suggested an efficacy of Ipamorelin in promoting insulin release from islet cells of the pancreas.[4] Studies suggest that the peptide may mediate the release of insulin through the indirect excitation of calcium channels found on the islet cells. The hypothesized mechanism of Ipamorelin action highlights the limitations of type 2 diabetes and further study may be of interest to researchers.
IPAMORELIN AS GHRELIN RECEPTOR PROBE
The peptide appears to bind strongly to the ghrelin receptor and may act as a selective agonist. Interestingly, the ghrelin receptor has been observed to increase cardiac failure and certain types of cancer, including carcinomas. Researchers have proposed studying Ipamorelin as a probe in positron emission tomography (PET) scans to help diagnose research models. [5] Further research is ongoing.
IPAMORELIN AND POST-OPERATIVE ILEUS
Post-operative Ileus (POI) is a condition characterized by an inability of the subject to accept oral nutrition as the GI system stops functioning. Ipamorelin has been studied in multiple proof-of-concept studies to determine its potential to reduce POI. It was found to shorten the time of uptake of the first meal by about 12 hours in POI models.[6] The researchers concluded that “ipamorelin accelerates gastric emptying in a rodent model of postoperative ileus through the stimulation of gastric contractility by activating a ghrelin receptor-mediated mechanism involving cholinergic excitatory neurons.” Some of the research observations in this and other studies suggest that residual radiolabeled food remaining in the stomach of rats with POI was less after the influence of Ipamorelin, even when compared to rats without POI.
Additionally researchers noted that when exposed to Ipamorelin, the geometric location of the food was observed to be similar for both rats without POI and those with POI. Furthermore, the radiolabeled food was located more distally in the GI tract and is similar to rats without POI, after Ipamorelin was given to rat models of POI.
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References
1.Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
2.Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999 Apr;9(2):106-13. doi: 10.1054/ghir.1999.9998. PMID: 10373343.
3.Andersen NB, Malmlöf K, Johansen PB, Andreassen TT, Ørtoft G, Oxlund H. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001 Oct;11(5):266-72. doi: 10.1054/ghir.2001.0239. PMID: 11735244.
4.Adeghate E, Ponery AS. Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro Endocrinol Lett. 2004 Dec;25(6):403-6. PMID: 15665799.
5.Childs MD, Luyt LG. A Decade’s Progress in the Development of Molecular Imaging Agents Targeting the Growth Hormone Secretagogue Receptor. Mol Imaging. 2020 Jan-Dec;19:1536012120952623. doi: 10.1177/1536012120952623. PMID: 33104445; PMCID: PMC8865914.
6.Greenwood-Van Meerveld B, Tyler K, Mohammadi E, Pietra C. Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. J Exp Pharmacol. 2012 Oct 19;4:149-55. doi: 10.2147/JEP.S35396. PMID: 27186127; PMCID: PMC4863553.
7.Sigalos JT, Pastuszak AW. The Safety and Efficacy of Growth Hormone Secretagogues. Sex Med Rev. 2018 Jan;6(1):45-53. doi: 10.1016/j.sxmr.2017.02.004. Epub 2017 Apr 8. PMID: 28400207; PMCID: PMC5632578.
